According to a recent study of 20 cities, more than 60% of men who have sex with men (MSM) are interested in pre-exposure prophylaxis (PrEP). Currently less than four percent participate in the therapy. Black and white respondents did not differ in their interest in taking PrEP. However, currently more white males take PrEP. Clinicians are urged to consider factors such as HIV incidence and prevalence in subgroups when discussing PrEP with patients.